Key words: nanoparticles, stimuli-responsive, tumor microenvironment, diagnosis, theranostics, clinical translation Introduction Since the discovery of the enhanced permeability and retention (EPR) effect and impaired lymphatic drainage of tumors [1], nanocarriers have been regarded as promising drug delivery vehicles to

These stimuli-responsive nanoparticles have demonstrated, though to varying degrees, improved in vitro and/or in vivo drug release profiles. In an effort to further improve drug release performances, novel dual and multi-stimuli responsive polymeric nanoparticles that respond to a combination of two or more signals such as pH/temperature, pH/redox, pH/magnetic field, temperature/reduction, double pH, pH and diols, temperature/magnetic field, temperature/enzyme, temperature/pH/redox

2020-06-24 · Such nanoparticles are responsive to both internal and external stimuli. Internal stimuli, such as pH, glutathione, reactive oxygen species, hypoxia and external stimuli, such as light, ultrasound, magnetic field and heat induced cell death, could be utilized for the development of stimuli responsive anti-cancer nanoparticles. Tokarev, I.; Minko, S. Tunable Plasmonic Nanostructures from Noble Metal Nanoparticles and Stimuli-Responsive Polymers. Soft Matter 2012, 8 (22), 5980–5987. 2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions.

Stimuli responsive nanoparticles

ABSTRACT Nanotechnology has become an outgrowing field in novel drug delivery system. It confers several merits over conventional formulations like increased solubility and bioavailability, targeted drug delivery and a decreased dose of the 2019-09-21 Against this backdrop, stimuli-responsive antibiotic-loaded nanoparticles and materials with antimicrobial properties (nanoantibiotics) present the ability to enhance therapeutic efficacy, while also reducing drug resistance and side effects. 2018-02-13 2019-01-10 Adapted with permission from ref. 30 (copyright 2015, American Chemical Society). (e) Reversible self-assembly of NPs controlled by a photoacid. Adapted with permission from ref. 31 (copyright 2015, Nature Publishing Group).

I am currently working in a project on stimuli-responsive drug delivery vehicles. These lipid nanoparticle carriers, liposomes, can be induced to release the drug

This Review provides a comprehensive discussion of Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications. Particles 2011 is an international conference examining the science, technology, and applications of stimuli responsive (functional) particles and particle assemblies in diverse application areas. The conference targets practicing scientists, clinical research physicians, engineers, managers, innovators, and entrepreneurs. Stimuli-responsive self-assembly of nanoparticles 1.

Use of PECs and PEMs from polymers and nanoparticles to create various functionalities, such as conductive, photo- or thermoresponsive, or.

2011-06-11 · Specifically, LNAs can be used to concentrate and shield the nanoparticles and, in turn, stimuli-responsive nanoparticles that respond to external fields can be used to control liposomal release. The ability to design LNAs via nanoparticle encapsulation, decoration or bilayer-embedment offers a range of configurations with different structures and functions. Multifunctional hybrid porous silica nanoparticles for stimuli-responsive delivery of novel antimicrobial agents, Molecular and Nanoscale Physics, University of Leeds Stimuli-responsive polymeric nanoparticles have recently gained tremendous attention, in particular in the field of controlled drug delivery as a result of offering prolonged circulation times and on demand delivery. Dual stimuli-responsive polypyrrole nanoparticles for anticancer therapy Rania M. Hathout 1, AbdelKader A. Metwally 1, Sherweit H. El-Ahmady 2, Eman S. Metwally 3, Noha A. Ghonim 3, Salma A. Bayoumy 3, Tarek Erfan 3, Rosaline Ashraf 3, Maha Fadel 4, Abdullah I. El-Kholy 4 and John G. Hardy 5,6 Stimuli-responsive co-delivery of oligonucleotides and drugs by self-assembled peptide nanoparticles Severin J. Sigg, Viktoriia Postupalenko, Jason T. Duskey, Cornelia G. Palivan, Wolfgang Meier* Department of Chemistry, University of Basel, Klingelbergstrasse 80, CH-4056 Basel, Switzerland KEYWORDS (2019). Overcoming the stability, toxicity, and biodegradation challenges of tumor stimuli-responsive inorganic nanoparticles for delivery of cancer therapeutics. Expert Opinion on Drug Delivery: Vol. 16, No. 10, pp.

He is Senior Editor of Insciences Journal, Nanotechnology Section. He supervised Stimuli Responsive Nanoparticles for Controlled Anti-cancer Drug Release. Curr Med Chem.
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Section B focuses on selected surface reactions that lead to responsiveness achieved by decorating nanoparticles with stimuli‐responsive polymers. Although grafting‐to and grafting‐from dominate these synthetic efforts, there are opportunities for developing novel synthetic approaches facilitating controllable recognition, signaling, or sequential responses. However, it is still a great challenge to fabricate nanoparticles with spatiotemporally controllable delivery of anticancer drugs to tumors and with high therapeutic efficacy.

Acid/base. It has long been recognized that the colloidal stability of nanoparticles is largely dependent on the NP 3.
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responsive nanoparticles. 4. Gases. As we have seen so far, reversible, stimuli-responsive self-assembly. of nanoparticles typically relies on the formation of noncovalent.

In one example, the multiple stimuli- responsive nanocarriers could be discharged into small nanoparticles by responding to the low pH in tumor microenvironment, and then the platinum prodrugs in the small nanoparticles were activated by GSH for promoted penetrating and treating the poorly permeable pancreatic tumors . Polypeptide nanoparticles composed of thiol-modified polylysine (PLL) are cross-linked with disulfide bonds and modified with poly (ethylene glycol) (PEG) and pH-sheddable dimethylmaleic anhydride (DMMA), which exhibit reduction- and pH-responsiveness.

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Stimuli-responsive nanoparticles have been designed and studied, exploring their potentiality as self-assembled materials as building blocks for the development of "smart" materials for bio-applications.

This thesis mainly focuses on the development of stimuli responsive nanoparticles for cancer targeted therapy. These nanoparticles either response to internal stimuli such as Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn 2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. The stimuli-responsive nanocarriers are mainly functionalized to delivery, release and activate cargos in specific regions (e.g., tumor microenvironments or intracellular spaces of cancer cells) by responding to internal/external stimuli, e.g., pH, enzymes, etc. [ 18, 19 ], while the ligand-installed nanocarriers are mainly applied to promote the specific internalization between nanocarriers and specific cells, e.g., … Using stimuli responsive core-shell particles to produce responsive colloidosomes from emulsion templates 73. Amihay Freeman (Tel Aviv University) Silver-coated biologically active protein hybrids: Biomedical applications 74.

W. Zhao et al., "In Situ Cross-Linking of Stimuli-Responsive "Combination of silica nanoparticles with hydroxyapatite reinforces poly (L-lactide

Grzelczak M (1), Liz-Marzán LM , Klajn R . Author information: (1)Donostia International Physics Center (DIPC), Manuel de Lardizabal 4, 20018 Donostia-San Sebastián, Spain.

Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy. A principal goal of cancer nanomedicine is to deliver therapeutics effectively to cancer cells within solid tumors. However, there are a series of biological barriers that impede nanomedicine from reaching target cells. This class of stimuli-responsive nanoparticles is inactive during blood circulation and under normal physiological conditions, but is activated by acidic pH, enzymatic up-regulation, or hypoxia once they extravasate into the tumor microenvironment.